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Therapeutic plasmapheresis

J W Bartges1

  • 1Department of Small Animal Medicine, Veterinary Teaching Hospital, University of Georgia, Athens 30602, USA.

Seminars in Veterinary Medicine and Surgery (Small Animal)
|August 1, 1997
PubMed
Summary
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Plasmapheresis removes disease-causing plasma components, returning healthy blood. This therapeutic apheresis is used for over 100 conditions, including autoimmune and infectious diseases.

Area of Science:

  • Medical Science
  • Therapeutic Apheresis

Background:

  • Plasmapheresis is a medical procedure that removes plasma containing disease-causing substances from the blood.
  • It targets protein-bound solutes, high-molecular-weight molecules, autoantibodies, and immune complexes.

Purpose of the Study:

  • To describe the principles and applications of plasmapheresis.
  • To highlight its role in managing various diseases.

Main Methods:

  • Removal of plasma from circulation.
  • Separation of plasma from blood components.
  • Return of remaining blood components with plasma or substitute.

Main Results:

  • Effective in removing autoantibodies, immune complexes, toxins, and other abnormal molecules.

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  • Demonstrated utility in treating over 100 diseases, including immune-mediated, neoplastic, infectious diseases, sepsis, hyperlipidemia, and thyrotoxicosis.

    • Conclusions:

    • Plasmapheresis is a versatile therapeutic apheresis technique.
    • It is particularly effective for rapidly reducing plasma antibody and immune complex levels in immune-mediated diseases.