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Update on antifungal resistance

M E Klepser1, E J Ernst, M A Pfaller

  • 1University of Iowa College of Pharmacy, Iowa City 52242, USA. michael-klepser@uiowa.edu

Trends in Microbiology
|September 19, 1997
PubMed
Summary

Overuse of antifungal drugs is driving resistance in Candida species, both naturally occurring and through genetic changes. Developing strategies for appropriate antifungal use is crucial to prevent further resistance.

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Area of Science:

  • Mycology
  • Antimicrobial Resistance
  • Clinical Microbiology

Background:

  • The widespread use of antifungal agents has led to significant challenges in treating fungal infections.
  • Candida species are common causes of opportunistic mycoses, and their resistance to antifungal drugs is a growing concern.

Purpose of the Study:

  • To highlight the impact of antifungal agent overuse on the selection and emergence of resistant Candida species.
  • To emphasize the need for strategic interventions to mitigate the development of antifungal resistance.

Main Methods:

  • Review of existing literature on antifungal resistance mechanisms in Candida.
  • Analysis of the relationship between antifungal agent usage patterns and resistance development.
  • Identification of genetic and subpopulation-based factors contributing to resistance.

Main Results:

  • Antifungal overuse selects for intrinsically resistant Candida species.
  • Genetic mutations and the proliferation of resistant subpopulations increase antifungal resistance.
  • Previously susceptible Candida strains are evolving resistance due to selective pressures.

Conclusions:

  • The escalating resistance in Candida species poses a significant threat to public health.
  • Implementing judicious antifungal stewardship is essential to curb the further emergence of antifungal resistance.
  • Further research into novel antifungal therapies and resistance monitoring is warranted.

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