[Hyperinsulinism in hyperlipoproteinemia in patients on a chronic hemodialysis program]

The aim of this study was to establish possible hyperinsulinemia, as a consequence of insulin resistance in chronic hemodialysis patients. We examined 45 HD (hemodialysis) patients and 18 healthy subjects. On an empty stomach the following parameters were established: glucose, insulin, triglycerides, total cholesterol, HDL (high-density lipoprotein)-cholesterol and LDL (low-density lipoprotein)-cholesterol. Body mass index and waist-hip ratio were also examined. Hyperlipoproteinemia was established in 22 patients (21 with type IV and 1 with type II b), while 23 patients were normolipidemic. Insulinemia was significantly increased in the group of patients with hyperlipoproteinemia, both comparing normolipidemic patients and healthy subjects (x1 = 20.7; p = 0.0001; x2 = 13.2, p = 0.0001; x3 = 11.3, p = 0.0001). In the group with hyperlipoproteinemia there was a positive correlation between levels of insulinemia and triglyceridemia (r = 0.41, p = 0.05). It can be concluded that hyperinsulinemia in the group of patients with hyperlipoproteinemia, on hemodialysis, is an imperative for treating insulin resistance, and in that way causes of lipoprotein metabolism disorders.