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Genetic approaches to study Rel/NF-kappa B/I kappa B function in mice
R M Attar1, J Caamaño, D Carrasco
1Department of Oncology, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA.
Seminars in Cancer Biology
|April 1, 1997
Summary
Genetic alterations in animal models reveal the critical role of Rel/NF-kappa B/I kappa B proteins in vertebrate immune system development and function. These transcription factors are essential for various biological processes.
Area of Science:
- Molecular Biology
- Immunology
- Genetics
Background:
- The Rel/NF-kappa B/I kappa B family comprises key transcription factors and regulatory proteins.
- These factors control genes vital for diverse processes including immune response and development.
Purpose of the Study:
- To review findings from genetically altered animal models (knockout and transgenic mice).
- To elucidate the in vivo function of Rel/NF-kappa B/I kappa B family members.
Main Methods:
- Generation of genetically altered animal models (knockout and transgenic mice).
- In vivo studies analyzing the function of Rel/NF-kappa B/I kappa B factors.
Main Results:
- Studies highlight the essential role of Rel/NF-kappa B/I kappa B factors in immune system development.
- These factors are crucial for immune system function in vertebrates.
Conclusions:
- Rel/NF-kappa B/I kappa B proteins are indispensable for vertebrate immune system development and function.
- Animal models are valuable tools for understanding gene family functions.