[Effect of several biologically active substances on the reactivity and immune response of the body]

Experiments were carried out with a total of 140 guinea pigs to study the effect of a tissue emulsion of swine embryos on some of the general defense reactions, the cell and humoral immunity of the organism in the treatment with an intact and a killed (with 3 per cent formalin) vaccine produced with two strains of Salmonella abortus ovis. Investigated were the phagocytic activity of the lung macrophages and the immobile cells of the reticulo-endothelial system in the spleen and the liver, the protein spectrum, the blood serum level of properdine, and the histologic changes in the parenchymal organs of the test animals. It was found that the application of a tissue emulsion simultaneously with the injection of the animals with an anti-Salmonella vaccine raised the unspecific reactivity of the organism. This was expressed with the rise of the gammaglobulin and properdine levels of the blood serum and the change in the immunologic pattern of the organism, an increase in the phagocytic activity of lung macrophages and RES immobile cells from 16 to 25 per cent, and the titer of agglutinins--from 10 to 32 times. Highest agglutinin titers of the blood and most active phagocytic defense were reached with the use of a vaccine having a whole antigen, combined with a tissue emulsion.