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Activation of the insular cortex during dynamic exercise in humans
J W Williamson1, A C Nobrega, R McColl
1University of Texas Southwestern Medical Center, Department of Physical Therapy, Dallas 75235, USA. jwill4@mednet.swmed.edu
The Journal of Physiology
|November 5, 1997
Summary
The left insular cortex activates during dynamic exercise, suggesting its role in regulating heart activity. Leg muscle signals also contribute to motor area activation during cycling.
Area of Science:
- Neuroscience
- Exercise Physiology
Background:
- The insular cortex is linked to cardiovascular control.
- Its specific function during dynamic exercise is not well understood.
Purpose of the Study:
- To investigate insular cortex activation during volitional dynamic exercise.
- To assess its role in regulating autonomic activity.
Main Methods:
- Eight subjects underwent active and passive cycling.
- Regional cerebral blood flow (rCBF) was measured using SPECT/MR imaging.
- Four subjects also had passive cycling with leg electrical stimulation.
Main Results:
- Increased rCBF was observed in the left insula during active cycling only.
- Leg primary motor areas showed greater rCBF increase with active cycling and passive cycling plus stimulation.
- No significant rCBF changes were noted in the right insula.
Conclusions:
- This study provides the first evidence of insular activation during human dynamic exercise.
- The left insular cortex may regulate cardiac autonomic (parasympathetic) activity.
- Leg muscle afferent input is crucial for motor area activation during exercise.