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Updated: Aug 25, 2026

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring
Published on: December 9, 2010
Three dimensional outer volume suppression for short echo time in vivo 1H spectroscopic imaging in rat brain
Y J Chen1, S Rachamadugu, E J Fernandez
1Interdisciplinary Graduate Program of Biophysics, University of Virginia, Charlottesville 22903, USA.
Abstract:
Three-dimensional in vivo spectroscopic imaging in rat brain requires additional localization to reduce the effects of lipid contamination. Outer volume suppression has been shown to be effective in two dimensions. We have extended this approach to three dimensions with additional outer volume suppression conforming to the shape of the rat brain. The technique suppresses the pericranial lipid effectively, allowing sampling of volumes close to the skull and effective localized shimming. These benefits permit three-dimensional 1H magnetic resonance spectroscopic imaging to be performed over most of the brain at shorter echo times, providing spectra more amenable to quantitative analysis.

