Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Gallbladder motility in laparoscopic cholecystectomy specimens

M Farghaly¹, M Khoursheed, H Dashti

¹Adam Hospital, Ministry of Health, Safat, Kuwait..

|January 1, 1997

Summary

Gallbladder contractility is reduced in patients with cholecystitis, impairing bile expulsion. Indomethacin, an anti-inflammatory drug, effectively blocks abnormal gallbladder rhythmic activity, suggesting a prostaglandin role.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The application of EPSiT in pilonidal sinus disease: an international Delphi consensus study endorsed by the Association of Laparoscopic Surgeons of Great Britain and Ireland (ALSGBI).

Techniques in coloproctology·2025

Same author

A retrospective cohort study to evaluate disease burden, health care resource utilization, and costs in patients with breast cancer in Dubai, UAE.

BMC health services research·2024

Same author

Occupational exposure to aluminum and its amyloidogenic link with cognitive functions.

Journal of inorganic biochemistry·2014

Same author

Correlation of serum alkaline phosphatase with clinicopathological characteristics of patients with oesophageal cancer.

Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit·2012

Same author

Low carbohydrate ketogenic diet prevents the induction of diabetes using streptozotocin in rats.

Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie·2011

Same author

Investigation of chronic toxicity of (14)C-fenitrothion and its degradation products on stored soybeans.

Environmental toxicology and pharmacology·2011

Area of Science:

Gastroenterology
Pharmacology
Physiology

Background:

Gallbladder dysfunction is common in cholecystitis.
Cholinergic stimulation plays a key role in gallbladder motility.
Inflammatory responses may impact gallbladder function.

Purpose of the Study:

To investigate in vitro gallbladder contractility in human and sheep gallbladders.
To assess the effects of carbachol and indomethacin on gallbladder motor responses.
To explore the role of prostaglandins in abnormal gallbladder activity.

Main Methods:

In vitro contractility assays using human and sheep gallbladder tissues.
Stimulation with carbachol to assess cholinergic response.
Administration of indomethacin to evaluate its effect on abnormal rhythmic activity.

Related Experiment Videos

Main Results:

Human gallbladders from cholecystitis patients showed hypocontractility (72% non-responsive) to carbachol.
Abnormal, regionally graded motor responses favoring bile propulsion were observed in 44% of gallbladders.
Abnormal early rhythmic activity (ERA) in 33% of patient gallbladders was blocked by indomethacin in 80% of cases.

Conclusions:

Gallbladder motility is reduced and impaired in patients with cholelithiasis and cholecystitis.
Abnormal gallbladder rhythmic activity appears to be prostaglandin-mediated and responsive to indomethacin.
Findings suggest impaired bile expulsion mechanisms in gallbladder disease.