[Methicillin resistant Staphylococcus aureus. A problem also in Sweden]

S Seeberg1, L Larsson

  • 1Infektionshygieniska Laboratoriet, Sahlgrenska Universitetssjukhuset, Göteborg.

Lakartidningen
|October 27, 1997
PubMed

Insights

Swedish hospitals rarely experience MRSA outbreaks. From 1983-1996, 209 MRSA cases were identified, with four outbreaks occurring in the 1990s. Standard precautions are vital for MRSA control.

Area of Science:

  • Medical Microbiology
  • Infectious Disease Epidemiology

Context:

  • Methicillin-resistant Staphylococcus aureus (MRSA) outbreaks are infrequent in Swedish healthcare settings.
  • Sahlgrenska University Hospital identified 209 MRSA cases between 1983 and 1996, involving 51 distinct strains.
  • An increase in imported MRSA infections was observed from 1990-1996, mirroring trends in high-prevalence neighboring countries.

Purpose:

  • To analyze the epidemiology of MRSA in a Swedish university hospital.
  • To investigate the occurrence and characteristics of MRSA outbreaks and imported cases.
  • To provide recommendations for effective MRSA control strategies.

Summary:

  • Retrospective analysis of 209 MRSA cases (1983-1996) at Sahlgrenska University Hospital revealed 51 different strains.
  • Four endemic MRSA outbreaks occurred during the 1990s, affecting 121 patients, primarily in intensive care and urology units.
  • The study highlights an increase in imported MRSA cases, correlating with higher prevalence in surrounding regions.

Impact:

  • Reinforces the importance of standard precautions, including hand hygiene and personal protective equipment, for all patient care regardless of MRSA status.
  • Provides insights into MRSA strain diversity and outbreak patterns in a low-prevalence setting.
  • Informs public health strategies for managing MRSA transmission in hospitals.

Related Concept Videos

Mismatch Repair01:48

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.The Mutator Protein Family Plays a Key Role in DNA Mismatch RepairThe human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
Antibiotic Selection01:45

Antibiotic Selection

Researchers use antibiotic resistance genes to identify bacteria that possess a plasmid containing their gene of interest. Antibiotic resistance naturally occurs when a spontaneous DNA mutation creates changes in bacterial genes that eliminate antibiotic activity. Bacteria can share these new resistance genes with their offspring and other bacteria. The overuse and misuse of antibiotics have created a public health crisis, as resistant and multi-resistant bacteria continue to develop.Antibiotic...
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...