Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

HL-A 27-associated arthritis

A C Keat, R M Barnes

    Rheumatology and Rehabilitation
    |May 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Most patients with seronegative arthritis carry the histocompatibility antigen Human Leukocyte Antigen-27 (HLA-27). This antigen is associated with distinct arthritis patterns, suggesting genetic influences and the need for unified nomenclature.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Progression of diabetic retinopathy after bariatric surgery.

    Diabetic medicine : a journal of the British Diabetic Association·2015
    Same author

    Determination of trace elements in biological materials by inductively coupled plasma spectroscopy with novel chelating resins.

    Biological trace element research·2013
    Same author

    Emission spectrometry.

    Analytical chemistry·2012
    Same author

    Switching anti-TNF therapy in ankylosing spondylitis.

    Rheumatology (Oxford, England)·2008
    Same author

    Influence of biologic therapy on return to work in people with work disability due to ankylosing spondylitis.

    Rheumatology (Oxford, England)·2008
    Same author

    Outcomes in verteporfin photodynamic therapy for choroidal neovascularisation--'beyond the TAP study'.

    Eye (London, England)·2004
    Same journal

    Parenteral iron therapy in the anaemia of rheumatoid arthritis.

    Rheumatology and rehabilitation·1982
    Same journal

    Diclofenac sodium, diflunisal and naproxen: patient preferences for anti-inflammatory drugs in rheumatoid arthritis.

    Rheumatology and rehabilitation·1982
    Same journal

    Polymyalgia rheumatica in a defined elderly community.

    Rheumatology and rehabilitation·1982
    Same journal

    The recovery of the severely disable stroke patient.

    Rheumatology and rehabilitation·1982
    Same journal

    Multisystem presentation of eosinophilic fasciitis.

    Rheumatology and rehabilitation·1982
    Same journal

    Group G streptococcal arthritis.

    Rheumatology and rehabilitation·1982
    See all related articles

    Area of Science:

    • Rheumatology
    • Immunogenetics
    • Clinical Medicine

    Background:

    • Seronegative arthritis affects patients without rheumatoid factor.
    • The Human Leukocyte Antigen (HLA) system plays a crucial role in immune responses.
    • Association between HLA-27 and specific arthritic conditions is known.

    Purpose of the Study:

    • To investigate the prevalence of the histocompatibility antigen HLA-27 in patients with seronegative arthritis.
    • To identify and characterize the principal clinical components of arthritis in HLA-27 positive patients.
    • To explore potential genetic influences and propose a unified nomenclature for these conditions.

    Main Methods:

    • Patient recruitment from routine rheumatology clinics.
    • Screening for the presence of the histocompatibility antigen HLA-27.

    Related Experiment Videos

  • Clinical assessment and categorization of arthritis presentation.

    • Main Results:

    • 71 out of 78 patients (91%) with seronegative arthritis possessed the HLA-27 antigen.
    • Four main arthritis patterns were observed: spondylitis, sacroiliitis, peripheral polyarthritis, and oligoarthritis.
    • A subset of patients with HLA-27 associated arthritis exhibited a milder disease course.

    Conclusions:

    • The strong association between seronegative arthritis and HLA-27 suggests a significant genetic link.
    • Distinct clinical presentations of arthritis in HLA-27 positive individuals may be influenced by separate genetic factors.
    • A unified nomenclature is proposed to encompass the various combinations of these arthritis components.