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Dermatomyositis associated with primary intramuscular B cell lymphoma
1Department of Dermatology, Oita Medical University, Japan.
The Journal of Dermatology
|December 31, 1997
Summary
This study describes a rare case of dermatomyositis complicated by primary intramuscular malignant lymphoma in a Japanese woman. The lymphoma cells, positive for CD20, were found in muscle tissue during treatment for dermatomyositis.
Area of Science:
- Rheumatology
- Oncology
- Pathology
Background:
- Dermatomyositis is an idiopathic inflammatory myopathy.
- Malignant lymphoma is a rare complication of dermatomyositis.
Observation:
- A 40-year-old Japanese woman with dermatomyositis developed thigh swelling during immunosuppressive therapy.
- Muscle biopsy revealed CD20-positive lymphoma cell infiltration.
Findings:
- The case represents primary intramuscular malignant lymphoma associated with dermatomyositis.
- A review of Japanese literature identified 12 similar cases between 1984 and 1996.
Implications:
- This association highlights the importance of considering lymphoma in dermatomyositis patients with unusual symptoms.
- Further research may elucidate the pathogenetic links between autoimmune diseases and lymphoid malignancies.