Jove
Visualize
Contact Us

Related Experiment Videos

[Superantigens in human disease]

E Rojas Ramos1, N Cisneros González, S M Cairo Cueto

  • 1Departmento de Immunología, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, IMSS.

Revista Alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)
|May 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Cell surface markers in patients with allergic rhinitis versus Der p and Der f challenge].

Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)·2001
Same author

[Advances in the study of immunopathology in atopic disorders].

Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)·2001
Same author

[Apoptosis in allergic disease].

Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)·2000
Same author

[The TH2 theory in allergy].

Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)·1999
Same author

[Effect of Staphylococcus aureus extract on the expression of L-selectin and LFA-1, in neutrophils from patients with allergic bronchial asthma].

Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)·1999
Same author

In vitro effect of complete Staphylococcus aureus extract on chemotaxis of polymorphonuclear cells in children with bronchial asthma and chronic relapsing upper airways infections.

Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)·1998
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Superantigens, proteins from bacteria like streptococci and staphylococci, trigger widespread T cell activation. This immune overreaction may cause various inflammatory diseases, including rheumatic fever and psoriasis.

Area of Science:

  • Immunology
  • Microbiology

Background:

  • Superantigens are potent microbial toxins.
  • They activate T cells non-specifically, leading to cytokine release.

Purpose of the Study:

  • To explore the role of superantigens in immune-mediated diseases.
  • To highlight superantigens as potential causative agents for specific inflammatory conditions.

Main Methods:

  • Review of existing literature on superantigen function.
  • Analysis of mechanisms linking superantigen activity to disease pathogenesis.

Main Results:

  • Superantigens interact with MHC class II and T cell receptors.
  • This interaction causes massive T cell proliferation and cytokine storms.

Related Experiment Videos

  • Potential links established between superantigens and diseases like rheumatic fever, arthritis, Kawasaki syndrome, atopic dermatitis, and guttate psoriasis.

    • Conclusions:

    • Superantigens possess significant immune-altering capabilities.
    • Their role in various inflammatory and autoimmune conditions warrants further investigation.
    • Consideration of superantigens as etiological factors in these diseases is crucial for understanding and treatment.