[The affinity binding of staphylococci with immobilized human plasminogen]

The phenomenon of the selective adhesion of staphylococci to immobilized human plasminogen was discovered and studied in the reaction of bacteriosorption. The study, made with S.aureus cells, strain Cowan 1, revealed that the degree of adhesion depended on the amount of immobilized protein and the time of its contact with bacterial suspension. The dose-dependent inhibition of adhesion with plasminogen and plasmin solutions, found to occur also with IgG, was demonstrated. Staphylococcal protein A did not inhibit adhesion. The plasminogen-binding receptor structure was shown to be highly sensitive to proteolysis, which is indicative of its protein nature.