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Related Experiment Videos

Is attention deficit hyperactivity disorder familial?

S V Faraone1, J Biederman

  • 1Department of Psychiatry, Harvard Medical School, Boston, Mass., USA.

Harvard Review of Psychiatry
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

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Attention deficit hyperactivity disorder (ADHD) is a familial disorder, supported by family-genetic studies. However, its exact transmission patterns and genetic subtypes require further research for better understanding.

Area of Science:

  • Psychiatry
  • Genetics
  • Developmental Psychology

Background:

  • Attention deficit hyperactivity disorder (ADHD) is a complex neurodevelopmental disorder.
  • Understanding the familial and genetic underpinnings of ADHD is crucial for diagnosis and treatment.
  • Previous studies suggest a familial component, but methodological issues warrant systematic review.

Purpose of the Study:

  • To evaluate methodologic issues in family studies of ADHD.
  • To determine if ADHD is consistently defined as a familial disorder across studies.
  • To analyze the familial transmission patterns of ADHD and its comorbidities.

Main Methods:

  • Systematic review of relevant literature.
  • Detailed overview of Massachusetts General Hospital family-genetic studies.

Related Experiment Videos

  • Analysis of studies using DSM-III and DSM-III-R definitions of attention deficit disorder and ADHD.
  • Inclusion of double-blind, controlled studies.

    • Main Results:

    • Evidence indicates that both attention deficit disorder and ADHD are familial disorders.
    • Familial transmission patterns suggest ADHD is distinct from anxiety and learning disabilities.
    • ADHD with conduct disorder may represent a familial subtype.
    • Major depression may be a variable expression of familial ADHD predisposition.

    Conclusions:

    • Strong evidence supports the familial transmission of ADHD.
    • The precise mode of ADHD transmission requires further investigation.
    • ADHD appears genetically heterogeneous, necessitating research into homogeneous subtypes.
    • Family-genetic studies are vital for clarifying ADHD etiology and nosology.