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Non-African Burkitt lymphoma presenting with oral thrush and an orbital mass in a child
C Edelstein1, J A Shields, C L Shields
1Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Purpose:
To report an unusual case of orbital involvement with non-African Burkitt lymphoma in a child.
Methods:
A 26-month-old boy developed oral thrush and painless right proptosis with eyelid swelling. Magnetic resonance imaging disclosed a diffuse mass involving the inferior, lateral, and superior right orbit and both maxillary sinuses. Incisional biopsy of the orbital mass was performed.
Results:
Histopathology disclosed diffuse infiltration of the orbital tissues by a high-grade lymphoid neoplasm that showed positive immunoreactivity for B-cell markers. Immunoglobulin gene rearrangement studies disclosed a characteristic t(8;14) translocation consistent with a small, noncleaved malignant lymphoma of the Burkitt type.
Conclusion:
Non-African Burkitt lymphoma may manifest with orbital involvement.