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Novel methods for studying new antiepileptic drug pharmacology
R H Mattson1, R D Scheyer, O A Petroff
1Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.
Advances in Neurology
|December 31, 1997
Abstract:
A number of new antiepileptic drugs act by indirect mechanisms and thus produce effects that may not best be measured by traditional blood studies of the drugs and their metabolites. Study of the indirect action of these drugs on GABA-mediated inhibition by microdialysis and nuclear MR spectroscopy has proved more relevant. These new investigative techniques may also prove valuable as compounds affecting glutamate or other excitatory neurotransmitters are developed.