Related Experiment Video
Updated: Aug 15, 2026

Isolation and Culture of Primary Mouse Keratinocytes from Neonatal and Adult Mouse Skin
Published on: July 14, 2017
[Adrenergic receptors in murine epidermis]
Abstract:
The availability of alpha- and beta-adrenergic receptors in murine epidermal cells was revealed by means of adrenomimetic and adrenolitic drugs, these receptors having direct influence on the cell division in epidermis. The simultaneous as well as independent stimulation of alpha- and beta-receptors by mesation (phenylephrine) and isadrin (isoproterenol), respectively, markedly inhibits the transition of epidermal cells from interphase into mitosis. The effect is observable in 2 hours. Thus, the interaction of adrenaline with adrenergic receptors in epidermis may be considered as a way by which this hormone may control the mitotic activity.
Related Concept Videos
Receptor Downregulation in MVBs
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR activation may...
Renewal of Skin Epidermal Stem Cells
Sensory Functions of the Skin
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
Cells of the Epidermis
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
Papillary Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Cholinergic Receptors: Muscarinic
The subtypes M1, M3, and M5 couple with the Gq subunit and activate the phospholipase C (PLC) activity, mobilizing intracellular Ca2+. Activation...

