[A comparative study of serum H-antibodies in typhoid patients and bacteria carriers]

A study was made of the dynamics of serum H-antibodies in typhoid patients depending on the period of the disease and the severity of its course; the blood sera of chronic carriers were examined as well. H-antibodies were determined in the indirect hemagglutination test with the use of erythrocyte H-dignoasticum. Antibodies of different physico-chemical nature (of IgG and IgM classes) were obtained by fractionation in columns with DEAE-cellulose. Results of the investigations showed that the titres of sum total serum H-antibodies failed to depend on the severity of the course of the disease. The maximum value of the mean geometrical titre of H-antibodies in the blood serum was determined on the 3rd-4th week from the onset of the disease. In chronic carriers the sum total H-antibody titres were greater than in typhoid patients. The serum H-antibody titres increased on account of IgG-globulins both in the typhoid patients and in carriers.