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Complement and immunity to viruses

P J Lachmann1, A Davies

  • 1SB Microbial Immunology Laboratory, Centre for Veterinary Science, Cambridge, UK. pjl1000@cam.ac.uk

Immunological Reviews
|January 7, 1998
PubMed
Summary
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Viruses are countered by the complement system, a key part of antiviral immunity. However, some viruses evolve strategies to evade complement activation, enabling them to cause disease.

Area of Science:

  • Immunology
  • Virology
  • Host-pathogen interactions

Background:

  • The complement system is a crucial component of the innate immune response, acting as an early defense against pathogens, including viruses.
  • Complement targets virus particles and infected cells, marking them for destruction by other immune mechanisms.
  • Despite its role, some viruses successfully infect humans, indicating effective evasion strategies.

Purpose of the Study:

  • To elucidate the role of the complement system in antiviral immunity.
  • To detail mechanisms of complement activation by viruses and infected cells.
  • To explore viral strategies for subverting complement-mediated immune responses.

Main Methods:

  • Review of existing literature on complement activation and viral evasion mechanisms.

Related Experiment Videos

  • Analysis of host-pathogen interactions at the molecular level.
  • Discussion of immunological strategies employed by viruses.

    • Main Results:

    • Complement activation is a primary defense against viral infections.
    • Viruses and infected cells can trigger complement pathways.
    • Viruses have evolved diverse mechanisms to inhibit or bypass complement activation.

    Conclusions:

    • The complement system plays a vital role in controlling viral infections.
    • Understanding viral subversion of complement is key to developing antiviral therapies.
    • Further research into these interactions can reveal new therapeutic targets.