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Evaluation of experimentally induced renal hypoperfusion using iron oxide particles and fast magnetic resonance
H Trillaud1, P Degrèze, Y Mesplède
1Service de Radiologie, Hôpital Pellegrin, Bordeaux, France.
Rationale And Objectives:
Renal perfusion can be evaluated with first-pass study of superparamagnetic iron oxide particles (SPIO). We applied this technique to a unilateral renal hypoperfusion model in rabbits.
Methods:
Turbo fast low-angle shot sequences (acquisition time = 440 msec), after bolus injection of SPIO (100-140 mumol/kg iron), were performed in two control groups (n = 5 in each) and one group (n = 5) with a left renal blood flow reduction caused by a surgical interrenal aortic ligature (140 mumol/kg iron). Qualitative and quantitative analysis using relative blood volume (rRBV), relative blood flow (rRBF), and mean transit time (MTT) were performed.
Results:
Signal changes were symmetric in control groups without significant differences between the kidneys. The experimental group showed a significantly delayed and less pronounced maximal reduction of signal related to a significantly decreased rRBF and increased rRBV and MTT in the left kidney (p < .05).
Conclusion:
This study shows the effectiveness of a dynamic magnetic resonance study using SPIO to detect unilateral kidney perfusion reduction.