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[Intoxication by diphenoxylate (author's transl)]

S García-Tornel, L Tobeña, J M Martín Rodrigo

    Anales Espanoles De Pediatria
    |May 1, 1976
    PubMed
    Summary

    Diphenoxylate, an antidiarrheal, can cause intoxication through hypersensitivity or overdose. This review of two cases suggests avoiding diphenoxylate in children under thirty months due to potential risks.

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    Area of Science:

    • Pharmacology
    • Toxicology

    Context:

    • Diphenoxylate is a commonly used antidiarrheal agent.
    • It functions by decreasing intestinal motility.
    • Diphenoxylate shares chemical similarities with meperidine.

    Purpose:

    • To present two cases of diphenoxylate intoxication.
    • To review the clinical signs associated with diphenoxylate toxicity.
    • To provide recommendations for the safe use of diphenoxylate.

    Summary:

    • Two cases of diphenoxylate intoxication are detailed, one due to hypersensitivity and the other to overdose.
    • Both patients experienced a favorable outcome following treatment.
    • Clinical manifestations of diphenoxylate intoxication were reviewed based on existing literature.

    Impact:

    • Highlights the potential dangers of diphenoxylate, particularly in vulnerable populations.
    • Suggests a specific age restriction for diphenoxylate prescription.
    • Informs healthcare providers about the recognition and management of diphenoxylate toxicity.

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