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Related Experiment Videos

The tip-top branching ureter

H Sariola1, K Sainio

  • 1Developmental Biology Research Programme, Institute of Biotechnology, Biocenter 1A, University of Helsinki, Finland. hannu.sariola@helsinki.fi

Current Opinion in Cell Biology
|January 13, 1998
PubMed
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Glial cell line derived neurotrophic factor (GDNF) is crucial for embryonic kidney development, regulating ureteric bud branching. This signaling molecule, expressed by mesenchyme, binds to the ureteric bud tip, guiding its growth and pattern formation.

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genetics

Background:

  • Organogenesis involves complex signaling between epithelial and mesenchymal tissues.
  • Epithelial branching patterns are critical for determining final organ structure and function.
  • Mesenchymal signals are essential for directing epithelial differentiation during organ development.

Purpose of the Study:

  • To identify signaling molecules regulating embryonic kidney branching morphogenesis.
  • To elucidate the role of Glial cell line derived neurotrophic factor (GDNF) in metanephric kidney development.
  • To characterize the GDNF signaling pathway in ureteric bud induction and orientation.

Main Methods:

  • Analysis of gene expression patterns in embryonic kidney rudiments.

Related Experiment Videos

  • In vitro studies on ureteric bud branching.
  • Biochemical assays to identify receptor components.

    • Main Results:

    • Glial cell line derived neurotrophic factor (GDNF) is expressed by the kidney mesenchyme.
    • GDNF binds to the tip of the ureteric bud, promoting its branching.
    • The GDNF receptor complex involves the Ret tyrosine kinase and GDNF family receptor alpha s.

    Conclusions:

    • GDNF is the first defined signaling molecule regulating ureteric branching in the embryonic kidney.
    • GDNF plays a key role in both inducing and orienting ureteric bud growth.
    • Understanding the GDNF pathway provides insights into kidney organogenesis and potential therapeutic targets.