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Detection of measles virus mRNA from autopsied human tissues
Y Katayama1, K Kohso, A Nishimura
1Department of Microbiology, Kobe University School of Medicine, Hyogo, Japan.
Journal of Clinical Microbiology
|February 12, 1998
Abstract:
By reverse transcription-PCR, measles virus (MV) mRNA was detected in the brain, kidney, spleen, liver, and lung tissues obtained from 23 (45.1%) of 51 autopsy subjects, with the detection rates of each tissue ranging from 8 to 20%. Sequence analysis revealed frequent mutations in the corresponding viral protein. These results suggest that MV mutants commonly persist in apparently healthy individuals.