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[Macrophages in asthma]

M A Medina Avalos1, M Orea Solano

  • 1Servicio inmunología clínica y alergia, Hospital Regional Lic. Adolfo López Mateos, ISSSTE.

Revista Alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)
|February 12, 1998
PubMed
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Mononuclear phagocytes, including alveolar macrophages, are increasingly implicated in bronchial asthma pathogenesis. These cells can induce inflammation by secreting mediators like IL-1, supporting their role in allergic diseases.

Area of Science:

  • Immunology
  • Pathogenesis of Asthma

Background:

  • Mononuclear phagocytes, such as alveolar macrophages, play a role in the pathogenesis of bronchial asthma.
  • These cells can be activated during allergic responses.

Purpose of the Study:

  • To explore the role of mononuclear phagocytes in asthma.
  • To investigate the inflammatory mediators secreted by these cells.

Main Methods:

  • Identification of Interleukin-1 (IL-1) in bronchoalveolar lavage fluid of asthmatic patients.
  • Identification of IL-1 in bronchoalveolar lavage fluid following allergen skin tests.

Main Results:

  • Mononuclear phagocytes, including macrophages, are increasingly recognized for their role in asthma.
  • Activated mononuclear phagocytes secrete inflammatory mediators, such as peptides, oxidation products, platelet activators, and arachidonic acid metabolites.

Related Experiment Videos

  • Interleukin-1 (IL-1) was identified in asthmatic patients' bronchoalveolar lavage fluid and after allergen skin tests.

    • Conclusions:

    • Mononuclear phagocytes are activated in allergic conditions.
    • These activated cells contribute to inflammation through the secretion of various mediators.
    • The presence of IL-1 supports the concept of mononuclear phagocyte activation in allergic diseases like asthma.