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[Macrophages in asthma]
M A Medina Avalos1, M Orea Solano
1Servicio inmunología clínica y alergia, Hospital Regional Lic. Adolfo López Mateos, ISSSTE.
Abstract:
Every time they exist more demonstrations of the paper than performs the line monocytes-macrophage in the patogenesis of the bronchial asthma. The mononuclear phagocytes cells, as the alveolar macrophages, also they can be activated during allergic methods. The monocytes macrophages are possible efficient inductors of the inflammation; this due to the fact that they can secrete inflammatory mediators, between those which are counted the pre-forming granules of peptides, metabolites of oxidation activation, activator of platelets activator and metabolites of the arachidonic acid. The identification of IL-1 in the liquidate of the bronchial ablution of sick asthmatic, as well as the identification of IL-1 in the I bronchioalveolar washing of places of allergens cutaneous prick, supports the activation concept mononuclear of phagocytic cells in allergic sufferings.
Insights
Mononuclear phagocytes, including alveolar macrophages, are increasingly implicated in bronchial asthma pathogenesis. These cells can induce inflammation by secreting mediators like IL-1, supporting their role in allergic diseases.
Area of Science:
- Immunology
- Pathogenesis of Asthma
Background:
- Mononuclear phagocytes, such as alveolar macrophages, play a role in the pathogenesis of bronchial asthma.
- These cells can be activated during allergic responses.
Purpose of the Study:
- To explore the role of mononuclear phagocytes in asthma.
- To investigate the inflammatory mediators secreted by these cells.
Main Methods:
- Identification of Interleukin-1 (IL-1) in bronchoalveolar lavage fluid of asthmatic patients.
- Identification of IL-1 in bronchoalveolar lavage fluid following allergen skin tests.
Main Results:
- Mononuclear phagocytes, including macrophages, are increasingly recognized for their role in asthma.
- Activated mononuclear phagocytes secrete inflammatory mediators, such as peptides, oxidation products, platelet activators, and arachidonic acid metabolites.
- Interleukin-1 (IL-1) was identified in asthmatic patients' bronchoalveolar lavage fluid and after allergen skin tests.
Conclusions:
- Mononuclear phagocytes are activated in allergic conditions.
- These activated cells contribute to inflammation through the secretion of various mediators.
- The presence of IL-1 supports the concept of mononuclear phagocyte activation in allergic diseases like asthma.