[The role of the complement system in the pathogenesis of yersinioses]

In 95 patients with Yersinia infections (yersiniosis and pseudotuberculosis) the character of changes in the complement system was studied, taking into account the functional activity of C1-C5, Co. The study demonstrated a decrease in the activity of the complement system in the dynamics of Yersinia infections and revealed quantitative changes of characteristics in yersiniosis and pseudotuberculosis. The results of the study suggest the mobilization of the complement system in Yersinia infections by the classical path of activation. Regularities of changes in the activity of C1-C5, Co, corresponding to the severity and clinical variants of Yersinia infections, make it possible to recommend the use of the above-mentioned parameters in the clinic of infectious diseases for evaluating the effectiveness of treatment and the course of the disease.