Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

TCF/LEF factor earn their wings

H Clevers1, M van de Wetering

  • 1Department of Immunology, University Hospital Utrecht, The Netherlands. h.clevers@lab.azu.nl

Trends in Genetics : TIG
|January 20, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium.

Oncogene·2024
Same author

Directed Differentiation of Murine and Human Small Intestinal Organoids Toward All Mature Lineages.

Methods in molecular biology (Clifton, N.J.)·2023
Same author

Correction: Patient-derived oral mucosa organoids as an in vitro model for methotrexate induced toxicity in pediatric acute lymphoblastic leukemia.

PloS one·2020
Same author

Patient-derived oral mucosa organoids as an in vitro model for methotrexate induced toxicity in pediatric acute lymphoblastic leukemia.

PloS one·2020
Same author

Airway organoids as models of human disease.

Journal of internal medicine·2020
Same author

Towards culturally competent paediatric oncology care. A qualitative study from the perspective of care providers.

European journal of cancer care·2017
Same journal

Genetic suppressors as new therapeutic targets for Mendelian diseases.

Trends in genetics : TIG·2026
Same journal

Beyond housekeeping: snRNA diversity, regulation, and human disease.

Trends in genetics : TIG·2026
Same journal

Rethinking mitochondrial metabolism: Intraindividual variability meets population constraints.

Trends in genetics : TIG·2026
Same journal

A role for epigenetics in rapid adaptation.

Trends in genetics : TIG·2026
Same journal

The myth of asexual fungi.

Trends in genetics : TIG·2026
Same journal

Rethinking molecular evolution through protein language model embeddings.

Trends in genetics : TIG·2026
See all related articles

Transcription factors TCF/LEF interact with beta-catenin in Wnt signaling. This interaction is crucial for development and cellular transformation, particularly in cancers with APC mutations.

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Cancer Biology

Background:

  • TCF/LEF transcription factors are conserved across species.
  • Beta-catenin is a key effector in Wnt signaling pathways.
  • The interaction between TCFs and beta-catenin is vital for developmental processes.

Purpose of the Study:

  • To elucidate the role of TCF/LEF factors and beta-catenin interaction in Wnt signaling.
  • To understand the mechanism of TCF/beta-catenin complex formation in development and cancer.

Main Methods:

  • Comparative analysis of TCF/LEF family proteins across different species.
  • Investigation of beta-catenin's role in Wnt pathway activation.
  • Examination of TCF/beta-catenin complex formation in APC-deficient and mutated cancer cells.

Related Experiment Videos

Main Results:

  • TCFs interact with beta-catenin to mediate axis formation in Xenopus.
  • Wingless/Wnt signaling leads to Armadillo/beta-catenin association with nuclear TCFs.
  • APC protein targets beta-catenin for destruction; mutations in beta-catenin lead to its accumulation and aberrant TCF target gene activation in cancer.

Conclusions:

  • The TCF/beta-catenin complex is a central bipartite transcription factor in Wnt signaling.
  • Aberrant transcriptional activation by beta-catenin is a key event in cellular transformation and cancer development.