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The "possible triangle" test for extreme discordant sib pairs
R Kruse1, S A Seuchter, M P Baur
1Institute for Medical Statistics, University of Bonn, Germany.
Genetic Epidemiology
|January 1, 1997
Abstract:
For the analysis of quantitative traits in nuclear families, extreme discordant sib pairs proved to be more powerful than unselected sib pairs. Here, we present a test that makes use of selected pairs and, in addition, restricts the parameters of the identical-by-descent distribution analogously to the "possible triangle" for affected sib pairs. In the Problem 2A data, extreme discordant sib pairs are selected. The analysis allowed the detection of most simulated major genes.