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A new method to modify the C-4 position of 10-deacetylbaccatin III
K Uoto1, H Takenoshita, T Ishiyama
1New Product Research Laboratories IV, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan.
Chemical & Pharmaceutical Bulletin
|January 20, 1998
Abstract:
We have developed a new method to modify the C-4 position of 10-deacetylbaccatin III (5) using the C-4 acetoxy anion of the 13-keto derivative (7) and various alkyl halides. The method developed herein should be very useful for the preparation of C-4 modified taxoid analogs.