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[Thrombolytic therapy in deep venous thrombosis. Initial clinical experience]
L C Albuquerque1, F Silveira, A J Zago
1Hospital São Lucas da Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre.
Arquivos Brasileiros De Cardiologia
|February 1, 1997
Summary
This study reports on treating deep venous thrombosis with streptokinase and tissue plasminogen activator. Effective venous recanalization was observed, though some patients experienced complications.
Area of Science:
- Vascular Medicine
- Interventional Cardiology
- Hematology
Background:
- Deep venous thrombosis (DVT) poses significant risks, necessitating effective treatment strategies.
- Thrombolytic therapy offers a potential avenue for restoring venous patency.
Observation:
- Four patients with proximal deep venous thrombosis (DVT) were treated using streptokinase and tissue plasminogen activator (tPA).
- Therapy was administered via venous infusion and monitored using ultrasonography with color Doppler.
- Treatment involved the direct administration of thrombolytic agents into the affected veins.
Findings:
- Complete lysis of thrombus was achieved in two out of four patients.
- The mean rate of venous recanalization across all cases was 88%.
- Two patients experienced reversible hemorrhagic complications, and one developed late venous insufficiency.
Implications:
- Streptokinase and tPA demonstrate potential efficacy in treating proximal DVT with high recanalization rates.
- Careful monitoring is essential due to the risk of hemorrhagic complications.
- Long-term follow-up is recommended to assess for potential venous insufficiency post-treatment.