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Related Experiment Videos

Why does Staphylococcus aureus secrete an Enterococcus faecalis-specific pheromone?

A Muscholl-Silberhorn1, E Samberger, R Wirth

  • 1Universität Regensburg, NWF III-Mikrobiologie, Germany. Albrecht.Muscholl@biologie.uni-regensburg.de

FEMS Microbiology Letters
|January 22, 1998
PubMed
Summary
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Staphylococcus aureus secretes staph-cAM373, a sex pheromone for E. faecalis. This peptide production is specific to S. aureus strains with the pAM373 plasmid, not coagulase-negative staphylococci.

Area of Science:

  • Microbiology
  • Bacteriology
  • Molecular Biology

Background:

  • Staphylococcus aureus produces staph-cAM373, a peptide functioning as a sex pheromone for Enterococcus faecalis strains harboring the pAM373 plasmid.
  • This interaction involves the induction of a specific adhesin encoded by the pAM373 plasmid in E. faecalis, leading to cell clumping.

Purpose of the Study:

  • To investigate the prevalence and specificity of staph-cAM373 production in Staphylococcus species.
  • To determine the relationship between staph-cAM373 production and bacterial growth or cell density.
  • To explore the potential role of staph-cAM373 in interspecies gene transfer.

Main Methods:

  • Screening of independent isolates of Staphylococcus aureus and coagulase-negative staphylococci for pheromone-inducing activity.

Related Experiment Videos

  • Assaying for the production of staph-cAM373 by quantifying its effect on E. faecalis clumping.
  • Comparing staph-cAM373 production levels with bacterial cell mass during growth.

    • Main Results:

    • 85% of S. aureus isolates produced staph-cAM373, while none of the coagulase-negative staphylococci isolates did.
    • Staph-cAM373 production was specific to the pAM373 plasmid and not observed with pAD1 or pPD1 plasmids.
    • Staph-cAM373 production correlated with cell mass, indicating it does not function as a quorum sensing molecule.

    Conclusions:

    • Staph-cAM373 production is a characteristic of specific Staphylococcus aureus strains carrying the pAM373 plasmid.
    • The peptide's production is not linked to quorum sensing in S. aureus.
    • Further research is warranted to understand staph-cAM373's role in facilitating gene transfer between E. faecalis and S. aureus.