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Related Experiment Videos

[Hypervitaminosis D in institutionalized elderly in Buenos Aires]

L Plantalech1, P Knoblovits, E Cambiazzo

  • 1Servicio de Endocrinología, Metabolismo y Medicina Nuclear, Instituto Agustin Rocca, Hospital Italiano de Buenos Aires, Argentina.

Medicina
|January 1, 1997
PubMed
Summary

Vitamin D deficiency is common in the elderly, leading to bone loss and secondary hyperparathyroidism. Maintaining adequate vitamin D levels is crucial for preserving bone mass in older adults.

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Area of Science:

  • Gerontology
  • Endocrinology
  • Bone Metabolism

Context:

  • Elderly populations in nursing homes at 34 degrees S latitude.
  • Studies on vitamin D deficiency often focus on areas with low solar irradiation.
  • This study investigates vitamin D status in a community with potentially higher solar irradiation.

Purpose:

  • To determine circulating vitamin D levels in elderly individuals.
  • To explore the relationship between vitamin D levels and bone metabolism markers.
  • To assess bone mineral density (BMD) in relation to vitamin D status.

Summary:

  • Low serum 25-hydroxyvitamin D (25(OH)D) levels were prevalent (14.4 + 1.7 ng/ml), with 40.5% below 10 ng/ml.
  • Evidence of secondary hyperparathyroidism (PTH: 169.4 + 30.9 pg/ml) and hypocalcemia (34.5%) was observed.

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  • Increased bone turnover was noted in those with vitamin D deficiency (hypovitaminosis D).

    • Impact:

    • Serum 25(OH)D levels positively correlated with forearm bone mineral density (BMD R33% and RUD).
    • Vitamin D deficiency was linked to increased parathyroid hormone (PTH) levels, indicating secondary hyperparathyroidism.
    • These findings highlight the critical role of vitamin D in maintaining bone mass and preventing bone loss in the elderly.