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Growth factors and hematopoietic stem cells
O P Veiby1, A A Mikhail, H R Snodgrass
1Progenitor, Inc., Columbus, Ohio, USA.
Hematology/Oncology Clinics of North America
|January 27, 1998
Abstract:
The hematopoietic system is mediated in part by cell-to-cell interactions and soluble mediators or growth factors (cytokines). A large number of cytokines directly and potently control hematopoietic stem and precursor cell proliferation and differentiation. This review focuses on the recent studies devoted to the role of cytokines in the ex vivo expansion and differentiation of hematopoietic stem and precursor cells.