[Comparison of three anti-nucleus antibody detection methods in different pathologies (author's transl)]

Anti-nucleus antibodies were detected in the blood sera of 232 patients of different pathologies by three diverse methods: a morphological method, and indirect immunofluorescent method and a radioimmunologic method. The results demonstrated the importance of the radioimmunologic method since this method displays anti-DNA antibodies which are specific in the active stage of lupus erythematosus (LE). Forthermore, the immunofluorescent method proved to be highly sensitive; and the morphological method can reveal different aspects of the LE phenomenon (such as nucleus phagocytosis) which can be indicative of an auto-aggressive process. Our survey indicates that simultaneous use of the three methods is advisable.