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Involvement of H2O2 production in cisplatin-induced nephrotoxicity
Y Tsutsumishita1, T Onda, K Okada
1Faculty of Pharmaceutical Sciences, University of Tokushima, Japan.
Biochemical and Biophysical Research Communications
|February 3, 1998
Abstract:
The purpose of this study was to elucidate the involvement of H2O2 production in cisplatin-induced nephrotoxicity. The S3 cells were more sensitive than OMCT cells in cell viability and H2O2 production during cisplatin treatment. The cytotoxicity and H2O2 production induced by cisplatin were terminated by treatment with catalase. In conclusion, we emphasize the importance of the hydroxy radical in cisplatin nephrotoxicity.