[From amyloid proteins to amyloidosis]
Related Experiment Video
Updated: Oct 30, 2026

Rapid Generation of Amyloid from Native Proteins In vitro
Published on: December 5, 2013
1Laboratoire de biochimie et génétique moléculaire, Hôpital Cochin-ICGM, Paris.
Abstract:
Amyloidosis, from a molecular point of view, is an extracellular deposition mainly constituted of low molecular mass proteins which are very rich in beta-pleated sheet structures. These proteins polymerase and self-assemble into insoluble fibrils which are resistant to proteases. Biochemically, the different forms of amyloidosis are classified according to the protein which is quantitatively the most important in the amyloid deposit. Most of the time it results from the proteolytic degradation of a plasma protein. This main protein is associated with a series of compounds, mainly of proteic nature, that are regularly found in all amyloid deposits.
More Related Videos
09:00Biochemical Purification and Proteomic Characterization of Amyloid Fibril Cores from the Brain
Published on: April 28, 2022
10:04Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging
Published on: October 20, 2017
Related Concept Videos
Amyloid Fibrils
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid Fibrils
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
The Proteasome
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. A series of enzymes carry out the ubiquitination of the target proteins - E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3...
The Proteasome
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. This involves participation of a series of enzymes including— E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3 (ubiquitin...
Proteoglycans
Alzheimer Disease ll: Pathophysiology