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[Gastroesophageal reflux]

W Schwizer1, M Fried

  • 1Departement Innere Medizin, Abteilung Gastroenterologie, Universitatsspital Zurich.

Therapeutische Umschau. Revue Therapeutique
|February 7, 1998
PubMed
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Gastroesophageal reflux disease (GERD) is a chronic condition often managed with acid-suppressive therapy, primarily proton pump inhibitors (PPIs). Surgery is reserved for severe cases refractory to medication.

Area of Science:

  • Gastroenterology
  • Internal Medicine

Context:

  • Gastroesophageal reflux disease (GERD) is a prevalent chronic disorder characterized by heartburn and regurgitation.
  • Many patients experience intermittent symptoms without seeking medical attention.
  • A significant long-term risk of GERD is the development of adenocarcinoma secondary to Barrett's metaplasia.

Purpose:

  • To outline the primary therapeutic strategies for managing GERD.
  • To discuss the role of prokinetic drugs and acid-suppressive therapy.
  • To review the indications for proton pump inhibitors (PPIs) and antireflux surgery.

Summary:

  • Two main GERD treatment strategies include prokinetic drugs targeting motility and acid-suppressive therapy reducing gastric acid.
  • Proton pump inhibitors (PPIs) are the cornerstone of GERD treatment, used intermittently for mild symptoms and long-term for severe, frequent relapses.

Related Experiment Videos

  • Helicobacter pylori eradication is not currently recommended for GERD patients. Antireflux surgery is effective but reserved for refractory cases due to associated morbidity and mortality.

    • Impact:

    • Provides a concise overview of current GERD management guidelines.
    • Highlights the importance of PPIs in controlling GERD symptoms and preventing complications.
    • Clarifies the limited role of H. pylori eradication and the specific indications for surgical intervention.