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Updated: Aug 4, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
Auditing prescription practice using explicit criteria and computerized drug benefit claims data
G M Anderson1, M H Beers, K Kerluke
1Institute for Clinical Evaluative Sciences, North York, Ontario, Canada.
Potentially inappropriate drug prescribing is common in the elderly, affecting 38% of antidepressant users. Older physicians and non-specialists are more likely to exhibit poor prescription practices.
Area of Science:
- Geriatric Medicine
- Pharmacology
- Health Services Research
Background:
- Improving healthcare quality requires aligning current practices with established guidelines.
- Drug prescribing patterns in the elderly are a key area for quality improvement.
Purpose of the Study:
- To estimate the prevalence of potentially inappropriate drug prescribing in the elderly population.
- To identify physician characteristics associated with inappropriate prescribing.
Main Methods:
- Utilized computerized claims data from a comprehensive drug benefit plan for the elderly.
- Applied explicit criteria for appropriate prescribing to identify instances of potentially inappropriate drug use.
- Analyzed the association between prescribing practices and physician demographics.
Main Results:
- 38% of elderly antidepressant recipients, 19% of oral hypoglycemic users, 18% of sedative hypnotic users, and 13% of NSAID users received potentially inappropriate drugs.
- Older physicians and those without specialty certification were more likely to prescribe potentially inappropriate medications.
Conclusions:
- Criteria-based audits of drug claims databases can identify population-level prescribing issues.
- Physician characteristics can predict suboptimal prescription practices.
- Claims data audits should be combined with other measures to fully assess care appropriateness and guide improvement strategies.
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