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Combination therapy by external fixation and functional bracing for infected open femoral fracture
Abstract:
It is well-known that an infected open fracture needs careful management. If the infected organisms are antibiotic-tolerant species such as Pseudomonas aeruginosa or methicillin-resistant Staphylococcus aureus (MRSA), treatment becomes quite difficult. Here we report that an open femoral fracture infected by these organisms was satisfactorily treated by the combination of external fixation and functional bracing without residual osteomyelitis.
Insights
Managing infected open fractures is challenging, especially with antibiotic-tolerant bacteria like Pseudomonas aeruginosa and MRSA. This study shows successful treatment of an infected femoral fracture using external fixation and functional bracing, preventing further bone infection.
Area of Science:
- Orthopedic Surgery
- Infectious Disease Management
- Biomedical Engineering
Background:
- Infected open fractures pose significant clinical challenges, particularly when caused by antibiotic-tolerant pathogens.
- Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus (MRSA) are common culprits that complicate treatment protocols.
- Effective management strategies are crucial to prevent complications like chronic osteomyelitis.
Observation:
- A patient presented with an open femoral fracture complicated by infection with antibiotic-tolerant organisms.
- Standard antibiotic therapies alone were insufficient to eradicate the infection.
- A combined approach utilizing external fixation and functional bracing was implemented.
Findings:
- The combined external fixation and functional bracing strategy effectively managed the infected open femoral fracture.
- Resolution of the infection was achieved without the need for further surgical intervention.
- No residual osteomyelitis was detected post-treatment.
Implications:
- This treatment approach offers a viable alternative for complex infected open fractures involving challenging bacteria.
- External fixation combined with functional bracing may reduce the incidence of chronic osteomyelitis.
- Further research into biomechanical and antimicrobial synergy in fracture management is warranted.