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Updated: Aug 14, 2026

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury
Published on: November 19, 2012
Transitory cognitive impairment with brief generalized spike-wave paroxysm: a clinical counterexample to the
1Electroneurodiagnostic Laboratory, University of South Alabama, Mobile, Alabama 36617, USA.
Abstract:
The topic of transitory impairment of consciousness with spike wave bursts has been of interest to neurologists for years. Based on some early experiments, a 3-second rule was formulated and has found its way into the conventional wisdom of neurology. It states that, in order to result in impairment of consciousness, a spike-wave burst must be of at least 3 seconds' duration. We discuss a case which poses a clinical counterexample to that rule.
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