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Mooren's ulcer: current concepts in management

V S Sangwan1, P Zafirakis, C S Foster

  • 1Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Boston, USA.

Indian Journal of Ophthalmology
|March 1, 1997
PubMed

Insights

Mooren's ulcer, a rare peripheral ulcerative keratitis, is an autoimmune corneal disease of uncertain cause. Immunosuppressive therapy shows promise for difficult cases.

Area of Science:

  • Ophthalmology
  • Immunology
  • Corneal Diseases

Background:

  • Mooren's ulcer is a distinct form of peripheral ulcerative keratitis (PUK).
  • It presents without associated scleritis or identifiable systemic causes.
  • The etiology of Mooren's ulcer remains largely uncertain.

Purpose of the Study:

  • To elucidate the autoimmune nature of Mooren's ulcer.
  • To explore recent advances in the management of this condition.

Main Methods:

  • Review of current literature on Mooren's ulcer.
  • Analysis of recent therapeutic outcomes.

Main Results:

  • Evidence suggests Mooren's ulcer is an autoimmune disease targeting corneal stroma.
  • Genetic susceptibility and environmental triggers are implicated.
  • Immunosuppressive therapy demonstrates increasing success.

Conclusions:

  • Mooren's ulcer is an autoimmune condition affecting the cornea.
  • Immunosuppression is a viable treatment for refractory and bilateral cases.

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