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Risk factors for mortality in Staphylococcus aureus bacteremia
L O Conterno1, S B Wey, A Castelo
1Infectious Diseases Division of Marilia Medical School, São Paulo, Brazil.
Infection Control and Hospital Epidemiology
|February 25, 1998
Summary
Staphylococcus aureus bacteremia has high mortality, particularly with lung infections or septic shock. Methicillin resistance in Staphylococcus aureus (MRSA) is also a significant risk factor for poor outcomes.
Area of Science:
- Infectious Diseases
- Clinical Microbiology
- Epidemiology
Background:
- Staphylococcus aureus bacteremia (SAB) is a serious infection with significant mortality.
- Methicillin-resistant Staphylococcus aureus (MRSA) poses a growing challenge in healthcare settings.
- Understanding risk factors for SAB mortality is crucial for effective patient management.
Purpose of the Study:
- To investigate the risk factors associated with mortality in patients with Staphylococcus aureus bacteremia.
- To determine the specific role of methicillin resistance in Staphylococcus aureus (MRSA) in predicting patient outcomes.
Main Methods:
- A nested case-control study was conducted.
- 136 patients with S. aureus bacteremia were analyzed, comparing those who died with survivors.
- Multivariate analysis was employed to identify independent predictors of mortality.
Main Results:
- The overall mortality rate within 14 days was 39%.
- Key independent risk factors for mortality included lung as the site of infection, occurrence of septic shock, and methicillin resistance in S. aureus (MRSA).
- Hospital-acquired infections and intravascular catheter-related infections were common.
Conclusions:
- Staphylococcus aureus bacteremia carries a high mortality risk.
- Lung infections and septic shock are major contributors to mortality.
- Methicillin resistance (MRSA) is identified as an independent risk factor for poorer outcomes in S. aureus bacteremia.