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The role of CpG dinucleotides in DNA vaccines
1University of Iowa, Dept of Internal Medicine, Iowa City 52242, USA. arthur-krieg@uiowa.edu
Trends in Microbiology
|March 3, 1998
Abstract:
DNA vaccines can induce potent humoral and cellular immune responses without any additional adjuvant. Recent studies indicate that unmethylated CpG dinucleotides within DNA vaccines are immune stimulatory and exert an essential endogenous adjuvant activity. These CpG motifs can be added deliberately to DNA or conventional protein vaccines to enhance the Th1 immune response.
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