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[Participation of N-methyl-D-aspartate receptors in modification of the frequency composition in rat
V V Vorob'ev1, E R Akhmetova, G I Kovalev
1Institute of Cell Biophysics, Russian Academy of Sciences, Moscow Region, Russia.
Abstract:
Injection of N-methyl-D-aspartate (NMDA) into the brain of nonanesthetized and nonimmobilized rats with chronically implanted electrodes in the brain cortex and cannula in its lateral ventricle caused dose-dependent augmentation of low-frequency (0.5-2.5 Hz) and diminution of high-frequency (9-20 Hz) components of the ECG spectrum. The specific antagonist of nmm the NMDA-subtype glutamate/aspartate receptors CPP removed the effects on EEG of subsequent NMDA administration. The results of experiments with D- and L-glutamate are indicative of the receptor character of the NMDA effects of intensification of the slow EEG rhythm related to the appearance of seizure activity in the brain.