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Observations on the A2 England influenza epidemic: a clinicopathological study

D Verel, A J Warrack, C W Potter

    American Heart Journal
    |September 1, 1976
    PubMed

    Insights

    This study details the 1972-1973 influenza A2 England epidemic, noting early myofibril necrosis in fatal cases and transient ECG changes in 18 home-treated patients. Some patients experienced permanent cardiac complications.

    Area of Science:

    • Cardiology
    • Virology
    • Pathology

    Background:

    • The 1972-1973 influenza A2 England epidemic prompted a clinicopathological investigation.
    • Understanding the cardiac manifestations of influenza is crucial for patient management.

    Observation:

    • Fatal cases within 24 hours of symptom onset showed early myofibril necrosis.
    • Gross pathological changes were observed at 5 days and largely resolved by day 18.
    • Transient electrocardiogram (ECG) changes were noted in 18 of 42 home-treated patients.

    Findings:

    • Observed ECG changes included ST-segment deviation, T-wave inversion, flattened T waves, sinus bradycardia, sinus tachycardia, nodal rhythm, and atrial fibrillation.
    • One patient developed permanent cardiac changes.
    • Another patient experienced permanent atrioventricular (A-V) block.

    Implications:

    • Influenza can lead to significant cardiac pathology, including transient and permanent changes.
    • Early detection and monitoring of cardiac involvement in influenza patients are essential.
    • This research highlights the potential long-term cardiovascular sequelae of severe influenza infections.

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