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Autonomy in endemic goiter

B Corvilain1, J Van Sande, J E Dumont

  • 1Institute of Interdisciplinary Research, School of Medicine, University of Brussels, Belgium.

Thyroid : Official Journal of the American Thyroid Association
|March 10, 1998
PubMed

The occurrence of hyperthyroidism in many individuals after introduction of iodine prophylaxis in endemic goiter areas can have dramatic consequences for the affected individuals. It indicates that in such individuals the increase of serum thyroid hormone level in response to iodine supplementation does not exert its normal negative feedback on thyroid activity, ie, that in such individuals some thyroid tissue has become autonomous. In this short review we summarize what is known about the possible mechanisms, cause, diagnosis, and consequences of thyroid autonomy.

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