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It's not just a phase: crystallization and X-ray structure determination of bacteriorhodopsin in lipidic cubic phases
1Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA. jeg52@columbia.edu
Structure (London, England : 1993)
|March 11, 1998
Abstract:
Utilization of lipidic cubic phases in the crystallization of bacteriorhodopsin (bR) has yielded long sought after crystals that diffract X-rays to 2 A resolution. The resulting structure provides new information on the protein conformation and the mechanism of proton translocation. Crystallization of bR via lipidic cubic phases may be a harbinger of new membrane protein crystallization strategies.