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Updated: Aug 9, 2026

Chromosome Preparation From Cultured Cells
Published on: January 28, 2014
The Philadelphia chromosome as a secondary change in leukemia: three case reports and an overview of the literature
Z Chen1, R Morgan, M Notohamiprodjo
1Genzyme Genetics, Scottsdale, Arizona, USA.
Abstract:
Three cases of acute nonlymphocytic leukemia with a Philadelphia chromosome (Ph) as a secondary abnormality are reported. The Ph was late-appearing in one patient and appeared as an additional anomaly in the other two patients. Fluorescence in situ hybridization studies of the first patient identified the presence of a minor BCR/ABL rearrangement. The findings of these cases support the conclusion that the Ph plays a role not only in leukemogenesis, but also in disease progression. An overview of the literature dealing with similar cases is also presented.
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