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Clinical multi-colour fluorescence imaging of malignant tumours--initial experience
K Svanberg1, I Wang, S Colleen
1Lund Medical Laser Centre and Department of Oncology, Lund University Hospital, Sweden.
Acta Radiologica (Stockholm, Sweden : 1987)
|March 14, 1998
Summary
This study introduces a novel multi-colour fluorescence imaging technique for non-invasive tumor detection. The method shows promise in identifying malignant and precancerous tissues, including early-stage carcinomas.
Area of Science:
- Medical imaging
- Oncology
- Biophotonics
Background:
- Traditional tumor detection methods like X-rays and endoscopy have limitations.
- Non-invasive techniques are crucial for early cancer diagnosis and patient management.
Purpose of the Study:
- To present a novel non-invasive tumor detection technique using multi-color fluorescence imaging.
- To evaluate the efficacy of this technique in various cancer types.
Main Methods:
- A multi-color fluorescence system was used for real-time imaging of skin, breast, head and neck, and urinary bladder tumors.
- Tumor detection relied on fluorescence contrast between normal and malignant tissues, utilizing agents like HPD and ALA.
- A laser-induced fluorescence system coupled with an endoscope captured and processed images in selected wavelength bands.
Main Results:
- Clear demarcation of superficial bladder carcinoma, basal cell carcinoma, and leukoplakia with dysplasia was achieved.
- In vitro investigations demonstrated clear demarcation of resected breast cancer.
Conclusions:
- Multi-color fluorescence imaging shows potential for detecting malignant and precancerous tissues, including early-stage carcinomas.
- Further research is required to fully develop and optimize this promising diagnostic method.