Related Experiment Video
Updated: Jul 13, 2026

Methods to Inhibit Bacterial Pyomelanin Production and Determine the Corresponding Increase in Sensitivity to Oxidative Stress
Published on: August 31, 2015
Inhibition of digoxin absorption by neomycin
The antibiotic neomycin sulfate significantly reduces the absorption of digoxin in humans. This interaction affects drug concentrations and excretion, impacting cardiac glycoside therapy.
Area of Science:
- Pharmacology
- Drug Interactions
- Gastrointestinal Absorption
Background:
- Digoxin is a crucial cardiac glycoside for managing heart conditions.
- Neomycin is an antibiotic with known effects on gastrointestinal function.
Purpose of the Study:
- To investigate the impact of neomycin sulfate on the absorption of orally administered digoxin in healthy volunteers.
Main Methods:
- Crossover studies were conducted in normal human volunteers.
- Varying doses of neomycin sulfate were administered with digoxin tablets.
- Serum digoxin concentrations, AUC, and urinary excretion were measured.
Main Results:
- Neomycin (1 and 3 g) markedly reduced serum digoxin levels, AUC, and urinary excretion.
- Neomycin delayed peak serum digoxin levels and inhibited absorption regardless of administration timing or formulation.
- Neomycin did not alter digoxin's terminal half-life when given after digitalization or affect d-xylose absorption.
Conclusions:
- Neomycin sulfate significantly depresses both the rate and extent of digoxin absorption in humans.
- The precise mechanism underlying neomycin's inhibition of digoxin absorption requires further investigation.
More Related Videos
10:01High-Throughput Optical Controlling and Recording Calcium Signal in iPSC-Derived Cardiomyocytes for Toxicity Testing and Phenotypic Drug Screening
Published on: March 31, 2022
08:03Hybrid Cell Analysis System to Assess Structural and Contractile Changes of Human iPSC-Derived Cardiomyocytes for Preclinical Cardiac Risk Evaluation
Published on: October 20, 2022
Related Concept Videos
Antiarrhythmic Drugs: Class I Agents as Sodium Channel Blockers
Class 1A Antiarrhythmic Drugs: These drugs work by moderately blocking sodium channels,...
Heart Failure Drugs: Inotropic Agents
Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations
Pharmacokinetics: Drug–Drug Interactions
Drug toxicity: Drug–Drug Interaction
Inhibitors of Bacterial Protein Synthesis