Related Experiment Videos
Dissolution rate of furosemide from polyethylene glycol solid dispersions
1Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Ankara, Tandoğan, Türkiye.
Farmaco (Societa Chimica Italiana : 1989)
|March 21, 1998
Summary
This study enhanced furosemide dissolution rates using solid dispersions with polyethylene glycols. The polyethylene glycols improved drug solubility and wettability, significantly increasing the release rate.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Furosemide is a poorly water-soluble drug, limiting its bioavailability.
- Solid dispersions are a strategy to improve the dissolution of poorly soluble drugs.
Purpose of the Study:
- To enhance the dissolution rate of furosemide.
- To investigate the effect of polyethylene glycol (PEG) molecular weight and drug-polymer ratio on furosemide solid dispersions.
Main Methods:
- Solid dispersions of furosemide with PEG (6000, 10,000, 20,000) were prepared using the fusion method.
- Characterization involved X-ray diffraction (XRD), differential scanning calorimetry (DSC), and infrared spectroscopy (IR).
- Dissolution rate was assessed using the flow-through cell method; particle size and stability were also studied.
Main Results:
- Solid dispersion formation was confirmed by characterization techniques.
- A significant increase in furosemide dissolution rate was observed with solid dispersions and even physical mixtures.
- Molecular weight of PEG, drug-polymer ratio, and particle size did not significantly impact the release rate.
Conclusions:
- Polyethylene glycols effectively enhance furosemide dissolution rate.
- The improvement is attributed to increased wettability and solubility provided by PEG.
- Solid dispersion technology offers a viable approach for improving furosemide's pharmaceutical performance.